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2022 Fiscal Year Final Research Report

Anti-inflammatory mechanisms of 1,3-diphenethylurea in watercress

Research Project

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Project/Area Number 21K13502
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionOsaka Metropolitan University (2022)
Osaka Prefecture University (2021)

Principal Investigator

Nakaya Makoto  大阪公立大学, 研究推進機構, 客員研究員 (90736886)

Project Period (FY) 2021-04-01 – 2023-03-31
Keywordsクレソン / 抗炎症効果 / ジフェネチルウレア / 可溶性エポキシヒドロラーゼ阻害
Outline of Final Research Achievements

Watercress (Nasturtium officinale), a leafy vegetable, contains 1,3-diphenethylurea (PE-UR). Focusing on the lipid mediators (LM) that control inflammation in vivo, we comprehensively analyzed the changes in LM by adding PE-UR to cultured cells and revealed that 14,15-Epoxyeicosatrienoic acid (14,15-EET), an anti-inflammatory material belonging to the CYP pathway, was increased in a dose-dependent manner. 14,15-EET is a substrate for soluble epoxyhydrolase (sEH) which metabolizes inflammatory LM. These results suggest that PE-UR increases the concentration of 14,15-EET, an anti-inflammatory LM, by inhibiting sEH. We believe that the sEH inhibition by PE-UR is the main mechanism underlying the anti-inflammatory effects of watercress ingestion.

Free Research Field

食生活科学

Academic Significance and Societal Importance of the Research Achievements

クレソンは欧米において伝統的に健康増進目的で食されているが、抗炎症効果を齎す機能性成分とその作用機序に科学的根拠が付与されていない。本研究の成果は、PE-URが機能性成分であることを、その作業機序と合わせ明確に示すものであり、食品の機能を評価する食生活科学の発展に貢献する。また、本研究の成果は、食品がもつ健康増進効果に明確な科学的根拠を提示する一例であり、伝統的な食品の価値を改めて社会に発信するものである。健康増進効果に着目した農作物の選択肢を消費者に提供し、国民の食生活をさらに豊かにする一助となる。

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Published: 2024-01-30  

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