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2023 Fiscal Year Final Research Report

Investigation of hemisphere laterality of abnormal auditory processing in schizophrenia

Research Project

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Project/Area Number 21K13753
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 10040:Experimental psychology-related
Research InstitutionUniversity of Miyazaki (2023)
Kyushu University (2021-2022)

Principal Investigator

Shunsuke Tamura  宮崎大学, 医学部, 助教 (20883333)

Project Period (FY) 2021-04-01 – 2024-03-31
Keywords神経オシレーション / 統合失調症 / 大脳半球左右差 / 音声 / 音楽
Outline of Final Research Achievements

In this study, we investigated the mechanism underlying hemispheric laterality in auditory information processing and its abnormality in schizophrenia by examining the neural activity phase-locking to temporal modulation of speech and music stimuli. Our findings suggest that the auditory cortex of the the right hemisphere is responsible for nonverbal auditory information processing that commonly occurs during both listening to speech and music stimuli, while the auditory cortex in the left hemisphere is activated when speech information processing is needed. In addition, we obtained the results indicating that the abnormal information processing in the auditory cortex of the left hemisphere in schizophrenia is speech-specific.

Free Research Field

精神神経科学

Academic Significance and Societal Importance of the Research Achievements

本研究では, 言語音声聴取時に左半球優位の脳内処理が働きにくいとされる統合失調症者を対象とした脳機能計測実験を行い, その異常が言語情報に特化した処理異常であるのか, 時間情報に特化した処理異常であるのかについて検討を行った。疾患研究を通して聴覚情報処理における大脳半球機能差のメカニズムについて議論を深めることが出来たことは学術的意義が非常に大きいと考えられる。また, 統合失調症において聴覚情報処理の大脳半球機能差を生み出すメカニズムを議論をすることはその主症状である言語性幻聴のバイオマーカーを発見することにもつながるため, 臨床的(社会的)意義も非常に大きいものだと考えられる。

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Published: 2025-01-30  

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