2023 Fiscal Year Annual Research Report
A common and potentially prebiotic activating agent for phosphorylation of nucleosides and oligomerization of nucleotides and amino acids
| Project/Area Number |
21K14029
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
蟻 瑞欽 東京工業大学, 地球生命研究所, 研究員 (00860090)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | amino acid / peptides / polymerization / chemical activation / RNA / nucleotides |
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| Outline of Annual Research Achievements |
cyanogen chloride was proposed to activate the synthesis of RNA and peptides. In this research, the activation of nucleotides to their 5′-phosphorimidazoles for RNA polymerization and activation of amino acids to peptides has been demonstrated. The cyanogen chloride activated polymerization of amino acids in the solid-phase peptide synthesis was also demonstrated, which could be used for the peptide synthesis in the industry. The activation of nucleotides to their 5′-phosphorimidazoles for RNA polymerization and amino acids polymerization has been found to occur in a one-pot synthesis using cyanogen chloride as a common activating agent. These results suggest that cyanogen chloride is a very useful activating reagent in the prebiotic chemistry.
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