2023 Fiscal Year Annual Research Report
Computational design of recognition peptide based plasmonic biosensor for small molecules detection
| Project/Area Number |
21K14169
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| Research Institution | Okayama University |
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Principal Investigator |
WANG JIN 岡山大学, ヘルスシステム統合科学学域, 准教授 (10870975)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | peptide / drug molecule |
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| Outline of Annual Research Achievements |
Small drug molecule, esculetin, are very important in adipose tissues, and regulates serum lipid profiles and shows potential anti-atherosclerosis benefits. In this stage, we use the computational design and molecular docking to simulate that the direct interaction between C/EBPβ and esculetin and conducted the research to clarify their reaction in vitro using optical sensor. These findings suggest that esculetin accelerates postprandial lipid circulation by binding to C/EBPβ and augmenting CD36-dependent phagocytosis in ATMs. The work was under review by Advanced Science. Furthermore, another novel designed peptide for TNT explosive was performed.
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