2022 Fiscal Year Annual Research Report
Light-activatable nanoparticles to treat triple negative breast cancers
| Project/Area Number |
21K14508
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
于 躍 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (90881631)
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | cancer / nanoparticle / phototherapy / cell signaling |
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| Outline of Annual Research Achievements |
Triple-negative breast cancer (TNBC) is usually aggressive, harder to treat, and more likely to come back. Wnt signaling is a potential therapeutic target because it is particularly activated in TNBC. However, disruption of Wnt signaling in non-cancerous cells also influences normal cellular functions. This research attempts to develop a targeted therapy for TNBC using a light-harvesting nanoparticle. In FY2022, we mainly investigated biological effects of these nanoparticles on TNBC growth, and elucidated the involved mechanisms in the context of Wnt signaling in response to light-driven nanoparticle treatment. The biocompatibility of nanoparticles was also evaluated using normal fibroblasts.
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