Evaluation of Photosensitivity by Difference in Molecular Size and Its Application to PDT

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K14597
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 32020:Functional solid state chemistry-related
• Research Institution: Hokkaido University
• Principal Investigator: Ide Yuki 北海道大学, 化学反応創成研究拠点, 特任助教 (40883070)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: 分子サイズ制御 / ポリケトン / calix[3]型環状化合物 / 結晶構造 / 金属錯体 / 吸収特性 / 環拡大反応

Outline of Final Research Achievements

Since differences in molecular size are known to modify the accumulation properties of compounds in tumor, the use of compounds with precise control of molecular length enables systematic assessment. Using a stepwise organic synthesis method, 2-10mers and up to 20mers of chain-like monodisperse polyketones with repeating units were successfully isolated. The potential of polyketones and polyimine analogues as functional materials was also confirmed by their ability to form complexes with metal ions. We focused on the synthesis of chain-like compounds (polyketone analogues) and cyclic compounds (calix[3]pyrrole analogues) with different molecular sizes based on polyketones. Structural analysis, spectroscopic measurements and characterisation using computational chemistry methods were performed.

Free Research Field

構造有機化学

Academic Significance and Societal Importance of the Research Achievements

段階的な有機合成手法を活用した分子長を制御可能な鎖状・環状化合物として、ポリケトン・ポリイミン類縁体ならびにcalix[3]pyrrole類縁体を利用する。分子サイズの精密な制御や目的とする機能に応じた骨格を有する錯体の設計が可能となり、電子状態や物性などの系統的な評価も可能となる。結果として、EPR効果への新たな知見を取り入れたPDT材料を含む機能性色素材料開発への発展が期待される。