Development of direct hydrogen atom transfer (HAT) catalyst driven by photoinduced intramolecular single-electron transfer

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K14625
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 33020:Synthetic organic chemistry-related
• Research Institution: Nagoya University
• Principal Investigator: Aramaki Yoshitaka 名古屋大学, 工学研究科, 助教 (70779678)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 水素原子移動 / 光触媒 / ホウ素 / 硫黄ラジカル / ブレンステッド酸触媒

Outline of Final Research Achievements

Methodology for directly converting carbon-hydrogen bonds in saturated hydrocarbon chains, which are abundantly present in organic compounds, offer an environmentally friendly alternative to conventional functional group-dependent synthesis by reducing waste and synthesis steps. However, the structures and reaction system of hydrogen atom transfer (HAT) catalysts capable of facilitating such direct carbon-hydrogen bond conversions are limited. Therefore, the development of novel HAT catalysts is required to achieve more diverse molecular transformations. In this study, we have successfully developed HAT catalysts based on a unique molecular design principle, enabling reactions that can not achieve high yields of the desired products using conventional methods.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究で開発した炭素－水素結合を直接変換できる新規触媒は、従来法では共存させることが難しかった素反応を組み合わせることができるため新たな分子変換法の開拓に繋がるとともに、単一の触媒で複数の機能を有することと、副生成物が生じないためアトムエコノミーにも優れ、環境調和性の非常に高い合成法である。加えて、本触媒設計は極めて汎用性が高く、本研究の触媒設計に則り独自の機能をもった新規光触媒の開発を促進するものとなりうる。