2022 Fiscal Year Final Research Report
Bioinspired underwater adhesives based on sequence-controlled polymer hydrogels
| Project/Area Number |
21K14676
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 35020:Polymer materials-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
Fan Hailong 北海道大学, 化学反応創成研究拠点, 特任准教授 (20897277)
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | hydrogel / underwater adhesion / sequence-control |
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| Outline of Final Research Achievements |
We established a facile method to synthesize polymers from the same pair of monomers but the different average sequences and studied the effect of the monomer sequence on the properties of polymers and related hydrogel materials. We discovered that the hydrogels with adjacent cationic-aromatic sequences exhibited strong adhesion in saline water. In medical applications, we discovered that polymer bearing adjacent cationic/aromatic sequences could glue the blood components together, forming a blood gel through electrostatic interactions in the physiological environment, which can work as a liquid embolic agent. We published 6 SCI papers and submitted 1 patent.
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| Free Research Field |
chemistry of materials
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| Academic Significance and Societal Importance of the Research Achievements |
We revealed that the monomer sequence plays a crucial role in determining the network structures and properties of hydrogels.We developed a revolutionary waterborne embolic agent for endovascular embolization treatment, based on a novel concept.
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