2022 Fiscal Year Final Research Report
Design of surface-segregatable polymers for anti-biofouling
| Project/Area Number |
21K14684
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 35020:Polymer materials-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | 高分子界面 / 精密重合法 / 表面濃縮 / 生体適合性 / 生体親和性 / 防汚特性 / 細胞接着抑制 / タンパク質吸着抑制 |
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| Outline of Final Research Achievements |
Surface modification without physical treatment or chemical reactions is necessary to induce anti-biofouling function on the surface. To clear this problem, we propose surface modifier which is added to the bulk material. We prepared bottle-brush poly[oligo(ethylene oxide methyl ether methacrylate)] and poly[oligo(dimethylsiloxane methacrylate)] block copolymer (EbS) as novel surface modifier. And then, EbS and poly(methyl methacrylate) (PMMA) blend film was evaluated cell adhesion behavior on this surface. In this results, EbS/PMMA blend film surface indicated the exhibition of high cell adhesion inhibition.
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| Free Research Field |
高分子界面
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| Academic Significance and Societal Importance of the Research Achievements |
材料表面に生体適合性を付与することは、小型化が進む医療診断デバイスの開発範囲を広げるために重要な課題である。本研究で得られた成果は，複雑な表面改質法を必要とせず、様々なバルク材料に表面改質剤を直接添加することにより、材料表面へ防汚特性を付与する事を示したものである。今後の研究の進展により、異物反応が抑制された環境下で診断用デバイスや細胞培養システムの構築が期待される。
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