Elucidation of the mechanisms of oxidative modification of skin lipids using LC-MS/MS and the development of control method by food functional ingredients

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K14800
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Tohoku University
• Principal Investigator: Ito Junya 東北大学, 農学研究科, 助教 (50781647)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: 皮膚脂質 / 酸化修飾 / LC-MS/MS / フェロトーシス

Outline of Final Research Achievements

With the aim of elucidating the effects of skin lipid oxidation on skin conditions and diseases and developing preventive and remedial methods using food functional ingredients, we aimed to (1) identify targets of skin lipid oxidation and evaluate their oxidation mechanisms, (2) clarify the physiological and physical effects of skin lipid oxidation modification, and (3) explore food functional ingredients for preventing skin aging and functional decline. We successfully achieved (1) by clarifying the oxidation mechanism of dermal lipids. In (2) and (3), we found that oxidative modification of skin lipids is related to ferroptosis and discovered potential food functional ingredients to prevent it.

Free Research Field

食品科学

Academic Significance and Societal Importance of the Research Achievements

皮膚は生体組織で最大の臓器であり、私たちを外部環境から守る生理的・物理的シールドとして常に機能を発揮している。「皮膚の酸化」は、皮膚の異常・老化（シミ、シワ、たるみ等）や乾癬、アトピー性皮膚炎、皮膚がんといった皮膚疾患に大きな影響を与え、QOLを著しく低下させることから、皮膚酸化の全容解明は、学術界・社会から強く要請されている。こうした現状の中で、本研究の成果は、皮膚の酸化が皮膚状態に与える影響の真の理解につながり、健全な皮膚状態の維持を実現できることから、社会的意義と波及性は極めて大きい。