2022 Fiscal Year Research-status Report
カルノシンの骨格筋再生における生理的役割の解明、および応用
| Project/Area Number |
21K14804
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | Carnosine / Muscle regeneration / Skeletal muscle / Vitamin B6 / sarcopenia |
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| Outline of Annual Research Achievements |
In this year, we further conducted experiments to determine if a carnosine regulator, vitamin B6, has any effects on muscle regeneration. We found that vitamin B6 deficient (1 mg PN* HCl/kg diet) and supplemented (35 mg/kg diet) diets significantly decreased carnosine levels in skeletal muscles, as compared to vitamin B6 recommended level diet (7 mg/kg diet). Next, we found that vitamin B6 deficiency (1 mg/kg diet) impaired muscle regeneration, reflecting by lower regenerating muscle mass and smaller myofiber size than the recommended vitamin B6 level (7 mg/kg diet) diet. Surprisingly, a high dose of vitamin B6 (35 mg/kg diet) also worsened muscle regeneration, which was against our expectation. Taken together the results suggest that the proper intake levels of vitamin B6 and higher levels of muscle carnosine are important to ensure the proper process of muscle regeneration. PN:Pyridoxine Hydrochloride
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
More research collaborators have joined my group so that more work can be done. So, everything has gone smoothly.
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| Strategy for Future Research Activity |
In FY 2023, effects of vitamin B6 on satellite cell activity will be examine by applying a single myofiber technique. In addition, effects of vitamin B6 on muscle hypertrophy in aging mice will be determined.
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