2023 Fiscal Year Annual Research Report
カルノシンの骨格筋再生における生理的役割の解明、および応用
| Project/Area Number |
21K14804
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | Carnosine / Muscle regeneration / Skeletal muscle / Vitamin B6 / sarcopenia / dexamethasone |
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| Outline of Annual Research Achievements |
In FY2023, effects of vitamin B6 on satellite cell activity and muscle atrophy have been examined. As a results, a vitamin B6 deficient diet exhibited a significant decrease in the quiescent satellite cell (SC) pool in mouse muscles, as compared to the vitamin B6 supplemented diet. By the single myofiber culture experiment, vitamin B6 deficiency suppressed the proliferation and self-renewal of SCs during myogenesis. In the dexamethasone-induce muscle atrophy model, we found that vitamin B6 deficiency aggravated muscle atrophy, while vitamin B6 supplementation attenuated muscle atrophy. Vitamin B6 supplementation significantly suppressed the up-regulation of Murf-1 and Atrogin-1 expressions in muscles, suggesting that vitamin B6 possibly attenuated muscle atrophy via preventing muscle degradation.
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Research Products
(15 results)
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[Journal Article] Exogenous Penicillium camemberti Lipase Preparation Exerts Prebiotic-like Effects by Increasing Cecal Bifidobacterium and Lactobacillus Abundance in Rats2023
Author(s)
Yongshou Yang, Huijuan Jia, Chika Ando, Hisanori Kato*, Thanutchaporn Kumrungsee*, Norihisa Kato, Akiko Kimoto, Shinji Fukuda, Manabu Kuroda, Kyoichi Nishio, and Shotaro Yamaguchi
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Journal Title
Fermentation
Volume: 9
Pages: 227
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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