2023 Fiscal Year Final Research Report
Preventive effects of dietary componets on aging related diseases
| Project/Area Number |
21K14820
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | エクオール / 加齢関連疾患 / 抗酸化作用 / 神経保護作用 |
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| Outline of Final Research Achievements |
Equol was suggested to prevent the onset of age-related hearing loss and bladder dysfunction associated with menopause, confirming its potential application as a preventive agent for these two age-related diseases. The mechanism is thought to involve antioxidant and neuroprotective actions in the periphery. In particular, the antioxidant effect is thought to be a suppression of lipid oxidation, and the neuroprotective effect is thought to be a reduction of damage to intermediate diameter filaments of Neurofilament and Peripherin, and prevention of denervation.
In summary, daily consumption of equol may be recommended as a beneficial treatment for the prevention and management of aging-related diseases.
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| Free Research Field |
抗加齢
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、大豆イソフラボンの一種であるエクオールは加齢関連疾患である閉経に伴う過活動膀胱および加齢性難聴の発症を予防することが示唆された。これはエクオールを日常的に摂取することが、加齢関連疾患に対して個人ができる予防医学として有効であることに加え、加齢関連疾患の進行を抑える治療法としても推奨される可能性があることを示している。また、今回明らかになったエクオールの神経保護作用の詳細なメカニズムを解明することは、加齢関連疾患の新たな治療標的の探索に寄与するだろう。
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