2022 Fiscal Year Final Research Report
Regulatory mechanism of glucose concentration sensing by nectin-1 in hypothalamic tanycytes.
| Project/Area Number |
21K15086
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 44010:Cell biology-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | 老化 / 視床下部 / 弓状核 / タニサイト / グルコース感知 / 神経幹/前駆細胞 / 細胞接着分子 / ネクチン |
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| Outline of Final Research Achievements |
The lifespan of various animals is prolonged by dietary restriction, but the regulatory mechanisms of aging and lifespan are largely unexplored. α2-Tanycytes, one of the tanycytes lining the lateral wall of the third ventricle of the hypothalamus, sense glucose concentrations in the cerebrospinal fluid and also have neural stem/progenitor cell functions in adults. It was recently reported that tanycytes are involved in extending murine lifespan, but it is unknown how tanycytes maintain these cell functions during aging. In this research project, I focused on one of the cell adhesion molecules nectin-1, which is specifically expressed in α2-tanycytes, and showed that nectin-1 inhibited tanycyte differentiation, maintaining their neural stem/progenitor cell function, which in turn regulates the maintenance of the number of neurons in the arcuate nucleus.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
これまでにタニサイトが個体の寿命延長に関与することが示されているが、成体においてタニサイトのグルコース濃度感知機能と神経幹/前駆細胞機能がどのように制御されているのかはほとんど解明されていない。本研究では、ネクチン-1によるタニサイトの神経幹細胞機能の維持機構の一端を解明した。この機構はグルコース感知機構の解明にも繋がると考えられる。今後は、ネクチン-1による神経幹細胞機能の維持機構を明らかにする。これらの成果は、個体の老化制御に重要なタニサイトの機能維持機構の解明につながることが期待されるため、本研究の学術的意義や社会的意義は非常に高い。
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