Reconstituion in vitro of primate germ cell development

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K15112
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 44020:Developmental biology-related
• Research Institution: Institute of Physical and Chemical Research (2022); Kyushu University (2021)
• Principal Investigator: Yoshimatsu Sho 国立研究開発法人理化学研究所, 脳神経科学研究センター, 客員研究員 (00882713)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: 生殖細胞 / マーモセット / 霊長類

Outline of Final Research Achievements

In this study, single cell analysis of germline cells from marmosets allowed us to identify primate-specific gene expression profiles, a major step toward future reconstruction in culture. Also, we generated reporter embryonic stem cell lines of marmosets harboring gonadal somatic cell-reporters. It would promote further studies for in vitro reconstitution of functional gametes from marmosets.

Free Research Field

生殖細胞生物学

Academic Significance and Societal Importance of the Research Achievements

本研究の継続よって、生殖細胞の再構築を検討する上で、近年深刻になっている少子高齢化や、不妊治療に対する根本的な解決策を創出できることがきたいされる。