2023 Fiscal Year Annual Research Report
Differential dopamine dynamics of DMS and DLS projecting SNc neurons during reversal learning
| Project/Area Number |
21K15184
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | Nigrostriatal system / Basal ganglia / Dorsal striatum / Motor control / Reinforcement learning / Dopamine |
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| Outline of Annual Research Achievements |
Our research revealed the critical roles of nigral dopaminergic and striatal output pathways in integrating reward expectation with motor actions. We demonstrated that both substantia nigra pars compacta (SNc) and dorsal striatum neurons reflect reward anticipation, enhancing the activity of direct and indirect pathway striatal projection neurons (dSPNs and iSPNs) similarly. This occurs alongside dopamine-mediated effects, where higher reward anticipation leads to a significant increase in action-related neuronal and dopamine release activities, challenging classical basal ganglia models. This study advances understanding of the dynamic interplay between reward expectation and motor control within the nigrostriatal system.
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