2023 Fiscal Year Final Research Report
Molecular mechanisms of postnatal amygdalar neurogenesis
| Project/Area Number |
21K15187
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Daun Kenny 滋賀医科大学, 医学部, 特任助教 (40896510)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | Postnatal amygdala / Neurogenesis / Early-life stress / Lineage tracing |
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| Outline of Final Research Achievements |
Neurogenesis in the postnatal amygdala remains unknown. We have previously found that neurogenesis in the amygdala was altered by environmental stimuli due to maternal and social deprivation (MSD) inflicted after birth. However, the details of its subtypes and origin are not clear. In this study, to infer the fate and origin of neonatal neurons in the amygdala, we performed amygdala lineage analysis of GFP-labelled neural stem cells (NSCs) after MSD, as well as single-cell RNA sequencing analysis and behavioral analysis to examine the differentiation trajectories of amygdalar neurogenesis and the physiological role of newborn neurons.
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| Free Research Field |
Neuroscience
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| Academic Significance and Societal Importance of the Research Achievements |
As newborn cells, particularly during the postnatal period, are context-sensitive, they can be manipulated by environmental stimuli. Understanding the contributions of amygdalar neurogenesis after early-life stress will provide new insight into fundamental aspects of brain plasticity.
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