2022 Fiscal Year Research-status Report
Discovery and characterization of a pressure sensation and transduction (PREST) mechanism in the presynaptic terminal in the CNS.
| Project/Area Number |
21K15203
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UCAR HASAN 東京大学, ニューロインテリジェンス国際研究機構, 特任助教 (50748423)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | Presynaptic terminal / mechanical stimulation / mechanobiology / PREST |
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| Outline of Annual Research Achievements |
We announced mechanical transmission and PREST in CNS in 2021 (Ucar et al., Nature, 2021).
I am studying the underlying mechanisms of PREST and we published a review article to underline its physiological importance for brain function and memory.
Recently I found that mechanical stimulation activates intracellular signaling pathways which lead to synaptic vesicle regulation during PREST. Here, synaptic vesicle clusters are mobilized upon mechanical stimulation and this is estimated to be regulated by a kinase pathway that I am working on.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
I was able to conlude that presynaptic terminal responds to mechanical stimulation and made a publication in Nature (Ucar et al. Nature 2021) and described PREST (pressure sensation and transduction) mechanism. Now I am studying underlying mechanisms for which I have promising data.
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| Strategy for Future Research Activity |
Now I am studying underlying mechanisms of PREST for which I have promising data. I will continue testing new molecular probes to understand the involvement of molecules for the regulation and function of PREST and their regulation by the intracellular kinases by using two-photon microscopy.
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Research Products
(4 results)
