2022 Fiscal Year Annual Research Report
Investigation of nucleus accumbens subpopulations controlling reward and aversive learning
| Project/Area Number |
21K15210
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| Research Institution | Osaka University |
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Principal Investigator |
マクファーソン トム 大阪大学, 蛋白質研究所, 助教 (40821898)
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | Reward / Aversion / Learning / Nucleus Accumbens / Basal Ganglia / In-Vivo Imaging / Optogenetics / Behavior |
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| Outline of Annual Research Achievements |
During this project, I was successful in using single-cell resolution in-vivo imaging and optogenetics to identify new subpopulations of nucleus accumbens cells that contribute to the signaling and reward and aversion, and can control reward and aversion-related behaviors. As a result of these exciting findings, i have now expanded the project further with the intention of publishing in a high-impact journal. This project has also directly contributed to data in several scientific papers that are now in submission or have been published, including one paper published in Nature Communications and another paper that is undergoing corrections at eNeuro.
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