2023 Fiscal Year Final Research Report
Carbocation generation without strong acids and the application to bond formation reactions
| Project/Area Number |
21K15223
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
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| Research Institution | Kyoto University (2022-2023)
Kanazawa University (2021) |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 光触媒 / カルボカチオン / ラジカル / ラジカルー極性交差反応 / コバルト触媒 / 有機硫黄光触媒 / 一電子移動 |
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| Outline of Final Research Achievements |
The generation of carbocation has required the use of strong acids, which lowered functional group compatibility and limited the application to synthesis of pharmaceutical drugs. In this research, a new approach to catalytic generation of carbocation from carboxylic acid derivatives and alkenes by a visible light-mediated organophotoredox catalysis has been provided. In our protocols, single electron transfer by a photoredox catalyst was utilized for carbocation generation. This strong acid-free protocol could be applied to functionalization of pharmaceutical drugs and natural products.
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| Free Research Field |
有機合成化学
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| Academic Significance and Societal Importance of the Research Achievements |
学術的意義：光触媒の一電子移動を活用することで、高反応性の化学種を従来法に比べて温和な条件下で発生させ、合成反応に利用できる可能性を示した。社会的意義：医薬品に多く含まれる炭素ーヘテロ原子結合をより温和かつ高効率で構築し、合成工程の簡略化や新たな合成戦略の掲示を通じて、創薬研究の加速に貢献する。
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