2022 Fiscal Year Final Research Report
Fundamental Study of Dental Floss for Caries Prevention based on Rheology and Drug Release Control
Project/Area Number |
21K15299
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 47060:Clinical pharmacy-related
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Research Institution | University of Shizuoka |
Principal Investigator |
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Project Period (FY) |
2021-04-01 – 2023-03-31
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Keywords | デンタルフロス / ナノファイバー / 薬物放出制御 / 持続放出 / 製剤学 / レオロジー / う蝕治療 |
Outline of Final Research Achievements |
Dental cleaning tools, such as dental floss, have gained attention as essential items for oral care in the prevention of dental caries and periodontal disease. In this study, we conducted foundational research for the development of sustained preventive dental floss products that can deform and release drugs in response to interdental structure and microenvironmental changes. We prepared acetyl phthalate cellulose-based nanofibers with directly encapsulated drugs and coated nanofibers with drug-encapsulated poly(lactic-co-glycolic acid) microspheres. The latter exhibited sustained drug release with initial burst inhibition compared to the former. Furthermore, the strength of floss made from these nanofibers was increased by the presence of drugs in the fibers for the former, while the latter maintained its strength.
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Free Research Field |
製剤学
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Academic Significance and Societal Importance of the Research Achievements |
我が国では様々なDDS技術と医療機器とを融合することが多いが、『日常で利用されるセルフケア用具との融合』に関しては申請者の知る限りほとんどない。また、現在国内外でデンタルフロスに機能性をもたせ、予防医療のための新たな機能性を有するデンタルフロス開発に関する報告は皆無であるため、本研究は新規性が高い世界初の技術開発のための基盤研究となったと考えている。本研究で開発する機能性デンタルフロスは、非侵襲的に歯間隣接部に微粒子製剤を送達・持続的に接着することで薬効を発揮することが想定され、口腔内衛生の持続的な保全が期待される。
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