• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2023 Fiscal Year Final Research Report

Functional role and pharmacological effects of macrophage-regulated peptides on ulcerative colitis.

Research Project

  • PDF
Project/Area Number 21K15422
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 49030:Experimental pathology-related
Research InstitutionKyoto Tachibana University

Principal Investigator

OKADA KOHKI  京都橘大学, 健康科学部, 専任講師 (80747569)

Project Period (FY) 2021-04-01 – 2024-03-31
Keywords潰瘍性大腸炎 / S100タンパク質 / マクロファージ / 組換えペプチド
Outline of Final Research Achievements

The purpose of this study was to clarify how a recombinant peptide of S100 protein affects the pathogenesis of ulcerative colitis (UC) rat model and the immune function of macrophages (MΦ). As a result, administration of rMIKO-1, an artificial peptide recombinant with rat S100A8, improved the pathogenesis of UC in rats. Although administration of rat S100A8 also improved the pathogenesis of UC, the pharmacological effect of rMIKO-1 administration was greater than that of rMIKO-1 administration. The application of rMIKO-1 to the treatment of UC is a future challenge.

Free Research Field

実験病理学

Academic Significance and Societal Importance of the Research Achievements

本研究はS100A8タンパク質の本質的な役割と, それを規定する一次構造の解明に繋がり, ひいては基礎免疫学の発展にも貢献できることから学術的に価値がある。UCは大腸組織に慢性炎症が生じ, 症状の寛解と再燃を繰り返す難病である。本研究は, UCの発症機序の解明や, UCを含む炎症性疾患における過剰な免疫反応の制御を目的とした治療薬の開発に繋がることが予想され, 社会的意義も大きい。さらに, 病態解析学や実験病理学, 薬理学分野などの発展にも貢献できる。本研究にて樹立したrMIKO-1は, MΦの異常な活性を律することで定常状態に導くため, UC以外の炎症性疾患に対する有益な効果も期待できる。

URL: 

Published: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi