Phylodynamics of regional Streptococcus pneumoniae serotype 19A-ST320 lineage in Okinawa prefecture and the analysis of pbp1a transmission between different pneumococcal clones in Japan

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K15432
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49050:Bacteriology-related
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Nakano Satoshi 国立感染症研究所, 薬剤耐性研究センター, 主任研究官 (30794987)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 肺炎球菌 / 全ゲノム解析 / 系統地理解析

Outline of Final Research Achievements

To clary the transmission route and the spread dynamic of Streptococci in a local region, we analyzed serotyepe 19A-ST320 isolates collected in Okinawa prefecture using whole genome sequencing. This clone is knows as one of the multi-drug resistant pneumococcal clones that was spread globally after the introduction of 7 valent-pneumococcal conjugate vaccine, however, it was endemic only in Okinawa prefecture in Japan.
Our study showed that the ancestor of the endemic 19A-ST320 isolates in Okinawa seemed to have imported from the U.S. before 2000 resulting in the regional spread in Okinawa, Japan.

Free Research Field

臨床微生物学

Academic Significance and Societal Importance of the Research Achievements

本研究は、高齢者の市中肺炎の最も主要な起炎菌の一つである肺炎球菌が海外から流入し、時間経過の後に地域流行を引き起こすことを提案するものである。