A mechanistic analysis of Trm competition for epidermal niche

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K15468
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Osaka University
• Principal Investigator: Hirai Toshiro 大阪大学, 微生物病研究所, 特任講師(常勤) (00895815)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: T細胞

Outline of Final Research Achievements

Tissue-resident memory T cells (Trm) are the non-circulating subset of memory T cells. It has been suggested that there is an upper limit to the number of Trm maintained in epidermis and that recruitment of new T cells clones into epidermis may result in the loss of past immune memory. Elucidating the mechanism of competition of Trm for epidermal niche, we analyzed roles of CD86 on Trm in steady state and during proliferation followed by re-encounter to specific antigen.

Free Research Field

ワクチン

Academic Significance and Societal Importance of the Research Achievements

Trmは、高い感染防御能を示すとともに、アレルギーや自己免疫疾患では病原性を示す。Trm同士の維持ニッチをめぐる競合機序に関する知見は、Trmの誘導や維持に関する機序を理解することにつながる。そのため、Trmをより効率よく誘導するワクチンの開発や、Trmが重要な病原性因子となるアレルギーや自己免疫疾患の新規治療法の開発等に役立つと考えられる。