2022 Fiscal Year Final Research Report
Targeting MiT transcription factors as a novel therapeutic approach to disru pt the adaptive response to microenvironmental stresses that gives rise to d ormant and cancer stem cell
| Project/Area Number |
21K15524
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 50010:Tumor biology-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | TFEB / TFE3 / PDAC / ISR / OSCAR / Transcription quescence / Dormancy |
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| Outline of Final Research Achievements |
In the first part, I have verified the initial hypothesis that proteins involve in cellular adaptive response to prevailing stress plays crucial role in cancer cells survival and the ability to thrive under metabolic and therapeutic stress. Through the use of genomics approaches (transcriptomics and genome-wide transcription factors binding site profiling) I have begun to elucidate the underlying molecular pathways associated with the function of the proteins mentioned above.
The existence of transcriptionally dormant cells within established isogenic culture cell lines had been demonstrated for the first time. This support the concept of cellular plasticity and highlight the validity of targeting dormant cells to cure patient.
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| Free Research Field |
Tumour biology
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| Academic Significance and Societal Importance of the Research Achievements |
Should this drug resistant dormant population that is responsible for relapse can be effectively targeted, we can improve overall survival, life quality of the patients (as they will need fewer rounds of chemotherapies) and reduce overall economic burden to the patient and society as a whole.
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