Malignant tumor treatment strategy using a combination of oncolytic virus and carbon nanotubes

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K15568
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Hiroshima University
• Principal Investigator: Sakuda Tomohiko 広島大学, 病院(医), 助教 (60878289)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 腫瘍溶解性ウイルス / 水疱性口内炎ウイルス / カーボンナノチューブ / 光温熱療法 / 骨肉腫 / 悪性腫瘍

Outline of Final Research Achievements

We investigated the tumor killing effect on osteosarcoma by combining the oncolytic effect of VSV and photothermal therapy using carbon nanotubes (CNT). Create an in vivo osteosarcoma mouse model, locally inject VSV and CNT solution, irradiate with near-infrared laser for 5 minutes per day for 6 consecutive days, remove the tumor margins, and confirm tumor volume and local recurrence. did. This reduced the primary tumor volume and lowered the local recurrence rate compared to VSV or CNT treatment alone. It was shown that the combination of the oncolytic effect of VSV and the photothermal therapy of CNTs led to the shrinkage of the primary tumor and may further contribute to the reduction of local recurrence after marginal resection.

Free Research Field

骨肉腫

Academic Significance and Societal Importance of the Research Achievements

骨肉腫に対する手術、なるべく低侵襲で患肢の機能を温存する治療が望まれるが、組織の温存範囲が大きくなるほど腫瘍細胞の残存による再発が懸念され、治療の侵襲性と根治性との間にはトレードオフの関係が存在する。本研究結果より腫瘍原発巣の完全根治と高い患肢機能温存(低侵襲手術)の両立を実現できる可能性があることが示唆された。