2023 Fiscal Year Research-status Report
Visual attention neuroprosthesis in marmoset to elucidate midbrain mechanisms of bottom-up attention
| Project/Area Number |
21K15609
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| Research Institution | Kyoto University |
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Principal Investigator |
Veale Richard 京都大学, 医学研究科, 助教 (80828880)
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| Project Period (FY) |
2021-04-01 – 2025-03-31
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| Keywords | Saliency map / Neuroprosthesis / Visual attention / Marmoset / Silicon Probe / Spiking simulation |
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| Outline of Annual Research Achievements |
We have collected data from silicon probe implantations in marmoset viewing free-viewing video, and prepared the complex software necessary for both statistical analysis of the gaze data, as well as estimation of parameters of models for predicting the gaze data given visual input (i.e. saliency maps). The next steps will be active stimulation and multi-probe implantations.
In addition, we have been collecting significant data from human infants and adults to confirm the application of the model beyond marmosets and to better understand the differences between species that may limit adoption of the prosthesis in humans.
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| Current Status of Research Progress |
Current Status of Research Progress
4: Progress in research has been delayed.
Reason
Due to limitations on experiment time, technical difficulties with surgery/implantation, and difficult developing the statistical software, the project is significantly delayed. However, I hope to show significant and interesting results within this final year.
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| Strategy for Future Research Activity |
It is possible that closed-loop stimulation will not be fully achievable by the end of the project. However, full model of marmoset SC and simulated expectation and sham stimulation should be possible in at least one animal. This year we plan to (1) continue free-viewing experiments with silicon probe recording from SC (2) Fit models (spiking network stimulation) and (3) attempt closed-loop stimulation. Additionally, we have prepared an animal for V1 lesion but it is unclear if recovery from the lesion will be ready before the end of this research grant (although we will publish the results aftewards).
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| Causes of Carryover |
Due to the delays in experimental time and software, it was necessary to delay many surgeries and experiments. They will be completed in this fiscal year as part of the original plan for the research project.
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