Research on the Comparison between Single Fraction and Multi-Fraction Radiation Therapy for Hemostatic Palliative Radiotherapy

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K15639
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: The University of Tokyo
• Principal Investigator: Katano Atsuto 東京大学, 医学部附属病院, 講師 (80822410)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 緩和医療 / 放射線治療 / 腫瘍出血 / 止血効果

Outline of Final Research Achievements

Radiation therapy plays a crucial role in various scenarios, such as vascular pathologies and tumor bleeding. However, the assessment of hemostatic response and the optimal schedule related to this treatment modality remains insufficient. To address this gap, we conducted an analysis targeting patients who underwent radiation therapy at our institution to elucidate the treatment's effectiveness and risk factors. Specifically, we evaluated the radiation therapy regimen and its effects based on patient data. Furthermore, considering patient background factors such as age, gender, clinical condition, pre-treatment physical status, primary tumor location and histology, presence of metastasis, and transfusion history, we analyzed the radiation therapy schedules influencing hemostatic response.

Free Research Field

放射線治療

Academic Significance and Societal Importance of the Research Achievements

がんに伴う症状緩和目的の放射線治療は欠かすことのできない治療オプションである。腫瘍出血に対する緩和照射のそも一つとして有用であるが、国内外ともに放射線治療の分割回数が腫瘍出血に与える影響を定量的に検討した報告は一部の報告に限られている。これを明らかにすることで、患者負担や介護者の負担を軽減することが可能である。また経済毒性の観点からも、不要な医療負担を省き、患者側からも国家経済の面からも有用である。