2022 Fiscal Year Final Research Report
Elucidation of the molecular basis of developmental disorders using a novel mouse model of gene duplication
| Project/Area Number |
21K15726
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | 発達障害 / 自閉症 / クロマチンリモデリング |
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| Outline of Final Research Achievements |
We generated autism risk factor Chd8 overexpressing mice. Our comprehensive behavioral analysis revealed that the transgenic mice manifested some behavioral abnormalities. Furthermore, we performed RNA-seq analysis with embryonic brains of these mice and found that the expression of genes related to neuronal differentiation was altered in the transgenic mice.
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| Free Research Field |
分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
CHD8遺伝子をノックインしたマウスの作製に成功した。さらにこのマウスは様々な行動異常を示すことから、発達障害のモデルマウスとしての有用性が示唆された。今後このモデルマウスを用いて発達障害の発症メカニズム解明や治療応用が期待される。
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