Exploration of central regulatory factors for radiosensitivity using high-precision genetic analysis and gene editing technology

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K15839
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Akita University
• Principal Investigator: Wakita Akiyuki 秋田大学, 医学部附属病院, 助教 (40610803)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 放射線感受性

Outline of Final Research Achievements

Treatment sensitivity of esophageal squamous cell carcinoma differs by individual. We previously reported that IGFBP3 expression is a radiosensitivity factor in esophageal squamous cell carcinoma. Recently, reports have shown that the oral environment adversely affects the prognosis and postoperative complications of esophageal cancer. In this study, we used esophageal squamous cell lines to examine the effect of Lipopolysaccharide (LPS) on cell proliferation and invasive potential. We demonstrated that exposure of esophageal squamous cell carcinoma cell lines to LPS enhanced CCL2 production and increased proliferative and invasive capacity.

Free Research Field

放射線感受性

Academic Significance and Societal Importance of the Research Achievements

CCL2は癌免疫の抑制や遊走能を増加させ、癌細胞の増殖に関わるとされている。食道扁平上皮癌細胞株はLPSによりCCL2産生し、増殖能および浸潤能が増加した。歯周病菌優位な不良な口腔内環境が食道扁平上皮癌の伸展及び予後に関係する重要な因子である可能性が示唆された。