2023 Fiscal Year Final Research Report
a novel microprotein MKMP78 in gastrointestinal tumor
| Project/Area Number |
21K15979
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | マイクロプロテイン / 大腸癌 / 細胞内代謝 / ミトコンドリア |
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| Outline of Final Research Achievements |
The purpose of this study was to elucidate the molecular mechanism of the novel microprotein MKMP78 in colon cancer and to examine the expression level of MKMP78 and its impact on patient prognosis.
MKMP78 was found to regulate cell proliferation in colon cancer cell lines. Further studies suggested that MKMP78 binds to and functions in concert with a mitochondrial protein X, suggesting that MKMP78 may regulate cell proliferation by regulating intracellular metabolism. This suggests that the protein may regulate cell proliferation by regulating intracellular metabolism. In addition, the expression of the protein was upregulated in patients with poorly differentiated colon cancer.
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| Free Research Field |
腫瘍学
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| Academic Significance and Societal Importance of the Research Achievements |
我々が独自に発見した新規マイクロプロテインMKMP78の生理的・臨床的意義はこれまで明らかにされていなかったが、本研究によりMKMP78が大腸癌の増殖・細胞内代謝を制御し、低分化型大腸癌の増殖に寄与する可能性が示唆された。
今後MKMP78をターゲットにした治療法が開発されることにより、低分化型腺癌の新規治療法の開発へとつながる可能性がある。
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