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2022 Fiscal Year Final Research Report

Analysis of the role of the dietary-derived factor genistein on intestinal epithelium

Research Project

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Project/Area Number 21K15991
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Kawamoto Ami  東京医科歯科大学, 医学部附属病院光学診療部, 助教 (70849124)

Project Period (FY) 2021-04-01 – 2023-03-31
Keywordsゲニステイン / イソフラボン / 潰瘍性大腸炎 / ヒト大腸上皮オルガノイド / チロシンキナーゼ
Outline of Final Research Achievements

In this study, functional analysis of the isoflavone genistein in the intestinal epithelium using patient-derived human intestinal epithelial organoids showed that genistein has inhibitory effects on the proliferative function of colonic epithelial stem/progenitor cells by selectively inhibiting both EGF and HGF receptors. Furthermore, genistein significantly delayed the wound healing response in a two-dimensional monolayer epithelial wound healing model using patient-derived colonic epithelial organoids. These results indicate that genistein may negatively affect the intestinal mucosa by suppressing stem/progenitor cell function, leading to persistent mucosal damage and possibly lead to the development of ulcerative colitis.

Free Research Field

消化器病態学

Academic Significance and Societal Importance of the Research Achievements

本邦においてクローン病に対し脂質制限や栄養療法が行われているがその詳細なメカニズムは明らかでない。食餌由来因子と炎症性腸疾患の発症・進展等について特定の食餌因子が腸上皮に対する直接作用を通じて疾患発症に関与し得る機序を示した報告はない。イソフラボン類は本邦で摂取量が多い食餌因子群であり、健康維持に正の効果を有する作用が広く認知されているが、本研究により同因子群のうち、ゲニステインは腸上皮を介した生体に対する負の作用を有し得る当方独自の知見を得た。従って本研究はイソフラボン類の新たな作用機序を明らかとし、今後新たな予防・治療法等への展開に寄与し得るものと考えている。

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Published: 2024-01-30  

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