Association between oxidative stress and Type2 inflammation in asthma

2023 Fiscal Year Annual Research Report

• Project/Area Number: 21K16117
• Research Institution: Kindai University
• Principal Investigator: 長崎 忠雄 近畿大学, 奈良病院, 講師 (40747862)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 喘息 / ヒト気道上皮細胞 / 酸化ストレス / 2型炎症

Outline of Annual Research Achievements

喘息患者で健常人に比し細胞内の還元型グルタチオン濃度が減少し、細胞外の酸化型グルタチオン濃度が上昇していること、および、喘息気道上皮細胞で細胞内および細胞外ともに酸化状態にシフトしていることを示した。
次に、酸化状態と臨床指標が関連することを示した。
また、細胞内の還元型グルタチオンが2型サイトカイン刺激で低下し、細胞外の酸化型グルタチオンが上昇することを示した。

Research Products

• [Journal Article] Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study (2024)
  • Author(s): Tashima Noriyuki、Matsumoto Hisako、Nishi Kenta、Terada Satoru、Kogo Mariko、Nomura Natsuko、Morimoto Chie、Sunadome Hironobu、Nagasaki Tadao、Oguma Tsuyoshi、Nakatsuka Yoshinari、Murase Kimihiko、Kawaguchi Takahisa、Tabara Yasuharu、Chin Kazuo、Sonomura Kazuhiro、Matsuda Fumihiko、Hirai Toyohiro
  • Journal Title: Allergology International Volume: 73 Pages: 65～70
  • DOI: 10.1016/j.alit.2023.04.005
  • Peer Reviewed
• [Journal Article] Sputum microbiota and inflammatory subtypes in asthma, COPD, and its overlap (2024)
  • Author(s): Morimoto Chie、Matsumoto Hisako、Nomura Natsuko、Sunadome Hironobu、Nagasaki Tadao、Sato Susumu、Sato Atsuyasu、Oguma Tsuyoshi、Ito Isao、Kogo Mariko、Tomii Keisuke、Tajiri Tomoko、Ohashi Kai、Tsukahara Takamitsu、Hirai Toyohiro
  • Journal Title: Journal of Allergy and Clinical Immunology: Global Volume: 3 Pages: 100194～100194
  • DOI: 10.1016/j.jacig.2023.100194
  • Peer Reviewed
• [Journal Article] Increased blood eosinophils and airflow obstruction as new-onset asthma predictors in the elderly: The Nagahama study (2024)
  • Author(s): Nishi Kenta、Nagasaki Tadao、Matsumoto Hisako、Oguma Tsuyoshi、Terada Satoru、Nomura Natsuko、Kogo Mariko、Tashima Noriyuki、Sunadome Hironobu、Murase Kimihiko、Matsumoto Takeshi、Kawaguchi Takahisa、Tabara Yasuharu、Matsuda Fumihiko、Sato Susumu、Chin Kazuo、Hirai Toyohiro
  • Journal Title: Allergology International Volume: 73 Pages: 236～242
  • DOI: 10.1016/j.alit.2023.11.002
  • Peer Reviewed
• [Journal Article] Associations between Nocturnal Hypoxemia and Retinal Nerve Fiber Layer Thinning: The Nagahama Study (2024)
  • Author(s): Nagasaki Tadao、Miyake Masahiro、Sato Susumu、Murase Kimihiko、Kawaguchi Takahisa、Matsumoto Takeshi、Nakatsuka Yoshinari、Mori Yuki、Ikeda Hanako Ohashi、Sunadome Hironobu、Hamada Satoshi、Takahashi Naomi、Togawa Jumpei、Wakamura Tomoko、Tabara Yasuharu、Tsujikawa Akitaka、Matsuda Fumihiko、Hirai Toyohiro、Chin Kazuo
  • Journal Title: Annals of the American Thoracic Society Volume: 21 Pages: 644～650
  • DOI: 10.1513/AnnalsATS.202304-355OC
  • Peer Reviewed
• [Journal Article] Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/obesity and low quality of life (2023)
  • Author(s): Nishi Kenta、Yoshimura Chie、Morita Kyohei、Ishikawa Ryoichi、Toyokura Erika、Nagasaki Tadao、Matsumoto Hisako、Nishizaka Yasuo
  • Journal Title: World Allergy Organization Journal Volume: 16 Pages: 100756～100756
  • DOI: 10.1016/j.waojou.2023.100756
  • Peer Reviewed
• [Presentation] 2型炎症におけるフェロトーシス (2024)
  • Author(s): 長崎忠雄
  • Organizer: 日本呼吸器学会
  • Invited
• [Presentation] 酸化ストレスと2型炎症 (2023)
  • Author(s): 長崎忠雄
  • Organizer: 日本呼吸器学会