The role of renal and urethral flora and related peptides in renal fibrosis

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K16160
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Mie University
• Principal Investigator: Nishihama Kota 三重大学, 医学部附属病院, 助教 (90832527)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: 腎線維化 / 細菌叢

Outline of Final Research Achievements

In mice treated with the microbiota-derived peptide corisin, urinary albumin excretion was increased in the renal fibrosis model compared to the control group, and pathological examination suggested progressive glomerular and tubulointerstitial fibrosis. These results suggest that corisin promotes renal fibrosis in the mouse model of renal fibrosis. In vitro experiments also showed that corisin and corisin-like peptides induced apoptosis in podocyte and Caki-2 cells, and co-stimulation with TGF-β and corisin enhanced apoptosis induction. These results suggest that corisin is involved in the induction of apoptosis in kidney-derived cells.

Free Research Field

代謝内分泌内科学

Academic Significance and Societal Importance of the Research Achievements

全ての腎疾患は末期腎不全に至る過程で腎線維化を伴うため、腎線維化の発生機序の解明と進行抑制は腎疾患の治療法の開発における重要な標的となる。今回の研究成果は常在細菌叢のマネジメントを通じて臓器線維化の進行の予測や進行の抑制を目指す新しい治療戦略につながるものと考える。