2022 Fiscal Year Final Research Report
Pathophysiological significance of renal energy metabolism in diabetic kidney disease
| Project/Area Number |
21K16166
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2023-03-31
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| Keywords | 糖尿病性腎臓病 / 脂肪酸酸化 / レニン・アンジオテンシン系 / エネルギー代謝 |
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| Outline of Final Research Achievements |
Dysfunction of renal energy metabolism has recently been reported to be associated with chronic kidney disease progression. In this study, we intended to investigate the pathophysiological role of renal energy metabolism in the development of diabetic kidney disease (DKD), using progressive DKD model mice. Compared to their wild-type control mice, levels of even-chain acylcarnitines, which reflect fatty acid oxidation (FAO) function, in the progressive DKD mice were broadly reduced along with significant alteration in FAO-related genes expression. These changes were restored by ARB treatment. The results of this study indicate that FAO dysfunction plays a certain role in the development of DKD and could become a new target to treat DKD.
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| Free Research Field |
腎臓・高血圧内科
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| Academic Significance and Societal Importance of the Research Achievements |
近年，腎臓のエネルギー代謝障害が，慢性腎臓病の進展に関わることが報告されているが，これまで糖尿病性腎臓病（DKD）における腎エネルギー代謝に関する報告は少なかった．本研究成果は，腎臓におけるエネルギー代謝の中でも，脂肪酸酸化（FAO）機能障害がDKD進展に関連していることを示唆しており，エネルギー代謝，特にFAOへの介入は，DKDに対する新しい治療候補となり得ることを明らかにした．
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