Spatial-temporal dynamics of genetic remodelling of the skin

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16210
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Kyoto University
• Principal Investigator: Ishida Yoshihiro 京都大学, 医学研究科, 助教 (70890622)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 乾癬 / アトピー性皮膚炎 / 皮膚がん / 紫外線 / 加齢 / 遺伝子変異

Outline of Final Research Achievements

We investigated how chronic skin inflammatory diseases such as psoriasis and atopic dermatitis affect the accumulation of mutations in the skin. The results showed that psoriasis is associated with an increase in the acquisition of driver mutations from a young age. On the other hand, few driver mutations were found in atopic dermatitis, suggesting that cells with driver mutations may be eliminated in this condition. While neither psoriasis nor atopic dermatitis itself generates mutations, many of the mutations are caused by ultraviolet light exposure.

Free Research Field

皮膚がん

Academic Significance and Societal Importance of the Research Achievements

本研究は、乾癬やアトピー性皮膚炎などの慢性皮膚疾患が遺伝子変異やクローン拡大にどのように影響するかを解明した。その結果、乾癬では皮膚がんリスクを高める遺伝子変異が多く見つかり、アトピー性皮膚炎では変異が抑えられることが分かった。これにより、乾癬の早期治療が皮膚がん予防に有効である可能性が示唆された。また、皮膚疾患の治療法や予防策の開発に役立つ新たな知見が提供された。