2022 Fiscal Year Final Research Report
Comprehensive search for therapeutic targets and understanding of fibrosis in hidradenitis suppurativa
Project/Area Number |
21K16214
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 53050:Dermatology-related
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Research Institution | University of the Ryukyus |
Principal Investigator |
Takuya Omine 琉球大学, 医学(系)研究科(研究院), 助教 (50880738)
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Project Period (FY) |
2021-04-01 – 2023-03-31
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Keywords | 化膿性汗腺炎 / 線維化 / サイトカイン |
Outline of Final Research Achievements |
Transcriptome analysis of lesions revealed that genes such as CTGF, COL1A1, COL3A1, COL14A1, and ELN were highly expressed in hidradenitis suppurativa compared to healthy controls and other diseases. High expression of genes associated with MZB1 cells, a group of B cells, was also observed. Immunostaining of hidradenitis suppurativa lesions revealed many MZB1-positive cells, which were CD79+, CD38+, CD138+, and CD20- cells, and co-stained with CTGF. When CTGF was added to healthy fibroblasts for 24 hours, high expression of COL1A1 and COL3A1 elastin was observed depending on the added concentration. These results demonstrate that MZB1 cells, a group of B cells, produce CTGF in hidradenitis suppurativa, leading to fibrosis in lesions.
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Free Research Field |
皮膚科学関連
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Academic Significance and Societal Importance of the Research Achievements |
化膿性汗腺炎は欧米では多くみられるが、東アジアでは比較的まれな疾患である。しかし、沖縄県はアジアの中では例外的に患者が多い地域であり、さらに性差などの臨床的な特徴も欧米と異なることがわかっている。遺伝的背景をもとに、病態が人種によって異なることが予想され、本研究を発信することは、治療法の開発も含め意義があり患者に還元できる可能性が高いと考える。
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