2023 Fiscal Year Final Research Report
Exposure to cigarette smoke extract underlies the pathogenesis of palmoplantar pustulosis via IL-17A-induced IL-36 production in tonsillar epithelial cells.
| Project/Area Number |
21K16232
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | smoking |
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| Outline of Final Research Achievements |
Palmoplantar pustulosis (PPP) is characterized by sterile pustules on the palms and/or soles. A strong association between PPP and tobacco smoking was reported and an elevated serum level of interleukin (IL)-17A in PPP patients was also reported. We investigated the relationship between the smoking index and the severity of the clinical condition of PPP, and the in vitro dynamics of IL-36 in human tonsillar epithelial cells under exposure to a cigarette smoke extract (CSE). Immunohistochemical examinations showed that IL-36 was highly expressed in tonsillar epithelial cells from PPP patients but not those from recurrent tonsillitis patients without PPP. The in vitro study revealed that IL-17A synergistically induced a release of IL-36 under the CSE exposure. These results suggest that a local production of IL-36 by epithelial cells induced by cigarette smoke exposure plays an important role in the pathogenesis of PPP.
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| Free Research Field |
dermatology
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| Academic Significance and Societal Importance of the Research Achievements |
The main findings in our study are that (1) smoking is involved in both the onset and the subsequent severity of PPP, especially in women; and (2) stimulation with the cigarette smoke extract significantly increased the expression of IL-36 in tonsillar epithelial cells.
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