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2022 Fiscal Year Final Research Report

Exploration of the origin of classic Hodgkin lymphoma cells by clonal and genetic analyses

Research Project

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Project/Area Number 21K16279
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 54010:Hematology and medical oncology-related
Research InstitutionNational Hospital Organization Nagoya Medical Center

Principal Investigator

SUZUKI Yasuhiro  独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 医師 (90898016)

Project Period (FY) 2021-04-01 – 2023-03-31
Keywordscomposite lymphoma / クローン解析 / PD-L1 / IgH::BCL2 / plasticity
Outline of Final Research Achievements

In classic Hodgkin lymphoma (cHL), the mechanisms of tumor pathogenesis and progression are not fully elucidated. We experienced a case with composite lymphoma (cHL and NK/T cell lymphoma) with identical clones and common PD-L1 abnormality and another case with synchronous lymphoma (cHL and follicular lymphoma) with identical clones. In this study, we analyzed these cases in detail pathologically and molecular genetically, and evaluated the relationship among these tumors. By these analyses, we explored the molecular mechanisms about the tumor origin and progression of cHL cells.

Free Research Field

血液内科学

Academic Significance and Societal Importance of the Research Achievements

ホジキンリンパ腫とのまれなcomposite/synchronous lymphoma症例を詳細に解析し、両腫瘍の関連性を追跡することにより、HRS細胞の腫瘍の起源ならびに進展の分子メカニズムの解析を行った。これらのまれなリンパ腫の詳細な解析により、腫瘍の可塑性(plasticity)や細胞系統をまたぐ転化(transdifferentation)に関する重要な知見を得ることができたことは学術的な意義があるものと考えられる。また、これらの知見はリンパ腫発症の病態解明のみならず、治療開発という点でも有用となる可能性が考えられた。

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Published: 2024-01-30  

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