Elucidation of pathogen survival factors

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16326
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54030:Infectious disease medicine-related
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Ryohei Hirose 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50795383)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 感染制御 / 環境消毒 / 残留消毒効果

Outline of Final Research Achievements

In 2021 (first year of research), we evaluated the disinfection effect against coronaviruses and influenza viruses on the human skin surface. In 2022 (second year of research), we evaluated the residual disinfection effect against viruses (coronaviruses and influenza viruses, etc.) on the human skin surface. In 2023 (third year of research), we constructed an evaluation model for the residual disinfection effect against Staphylococcus aureus, including MRSA, Escherichia coli, including enterohemorrhagic E. coli, and Serratia marcescens.
Finally, this study collected the data necessary to develop a method for creating a skin environment that is not suitable for survival for viruses and bacteria.

Free Research Field

感染制御

Academic Significance and Societal Importance of the Research Achievements

実使用条件を忠実に再現した消毒効果評価試験を確立した。この試験に基づき開発・承認された新規消毒薬や消毒方法は、実際の使用条件においても十分効果を発揮し実使用での効果との乖離は消失する。手指衛生・接触感染予防の進歩に大きく貢献する。
加えて、病原体が長期生存しにくい皮膚表面環境つまり接触感染に強い皮膚表面環境の創出技術を構築した。Super Spreader等の皮膚上の病原体不活化因子の少ない個人に対して、病原体が生存しにくい皮膚表面環境を創出できる方法を構築する。手洗い・手指消毒の前段階となる革新的な手指衛生法として、病原体が生存しにくい皮膚環境の創出は斬新かつ有効な予防手段となる。