MRI hemodynamic analysis of portal vein flow after liver resection/liver transplantation

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K16472
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Kyoto University
• Principal Investigator: Ogiso Satoshi 京都大学, 医学研究科, 助教 (10804734)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Keywords: 門脈 / 血流 / 肝切除 / 肝移植 / MRI / 血流解析

Outline of Final Research Achievements

The project analyzed portal vein flow after liver resection usign 7-tesla MRI to understand mechanism of small-for-size syndrome development. Portal vein flow parameters in 70%- and 90%-hepatectomized mice/rats were successfully obtained using 7-tesla MRI during the post-hepatectomy first week. Based on blood flow parameters of 2nd-order portal branches and corresponding parenchymal volumes, post-hepatectomy increase in portal flow volume per parenchymal volume was associated with portal poressure and liver regenerated volume. In contrast, wall shear stress, which is often considered as a trigger of liver regeneration, did not significantly increase in the process of liver regeneration.

Free Research Field

肝臓外科

Academic Significance and Societal Importance of the Research Achievements

肝切除後の門脈枝における血流指標変化が非侵襲的かつ客観的に評価出来るようになり、また得られた指標によってその後の肝臓の容量・機能の回復過程が予測できるようになることで、肝切除後および肝移植後の管理が改善し治療成績につながることが期待される。また、本研究の知見をさらに末梢の解析へ展開することにより、類洞レベルにおける血流指標が肝臓の発生や再生へ与える影響の理解に繋がる。これにより、肝臓外科・肝移植医療の成績向上だけではなく、門脈内皮細胞や肝細胞を用いた３次元再生臓器の成熟化技術への応用なども期待される。