Evaluating the Effectiveness of Goal-Directed Perfusion in ECMO therapy

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16502
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Juntendo University
• Principal Investigator: MUKAIDA HIROSHI 順天堂大学, 医療科学部, 講師 (10865679)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 目標指向型体外循環 / 急性腎障害 / せん妄 / 人工心肺 / 酸素供給量

Outline of Final Research Achievements

Organ injury caused by inadequate perfusion during cardiopulmonary bypass (CPB) remains an unresolved issue. We investigated the correlation between postoperative delirium and renal dysfunction in patients undergoing goal-directed perfusion, in which parameters such as oxygen delivery and body temperature are controlled to target values through continuous monitoring of the oxygen supply and demand balance during CPB. The study found an association between postoperative delirium and low hematocrit levels in patients undergoing goal-directed perfusion. The results suggest that goal-directed perfusion is effective not only in increasing pump flow but also in highlighting the importance of perioperative hemodilution management. Additionally, postoperative acute kidney injury was found to be associated with rewarming times over 36°C, suggesting that shortening the rewarming time is effective.

Free Research Field

人工心肺

Academic Significance and Societal Importance of the Research Achievements

体外循環は心肺機能を強力に補助することが可能な優れた治療法である。一方では不適切灌流が原因と考えられる臓器機能障害が発生することも知られている。本研究では体外循環管理方法と臓器機能障害との関係を調査し、合併症リスクを低減した人工心肺管理方法を提言することができた。本研究成果から合併症発生機序解明へ発展することができ、体外循環管理技術の向上に寄与すると考えられる。