Four-dimensional dynamic respiratory computed tomography for investigation of patient self-inflicted lung injury and its application to respiratory management.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16594
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Jichi Medical University
• Principal Investigator: KATAYAMA Shinshu 自治医科大学, 医学部, 講師 (70645704)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 4D-CT / 呼吸ダイナミックCT / 自発呼吸誘発性肺傷害 / 人工呼吸関連肺傷害 / 人工呼吸 / EIT

Outline of Final Research Achievements

This is a novel clinical study in which ventilatory dynamics during spontaneous breathing in patients on ventilatory management were analysed using four-dimensional respiratory dynamic CT (4D-CT). In this study, the accuracy of 4D-CT was validated and proved to have very high phase and accuracy precision.
The pendelluft phenomenon, which could only be observed with EIT, was found to be reproducible with 4D-CT. This enables analysis of anatomical changes that could not be seen with the low spatial resolution of EIT with the high spatial resolution characteristic of CT, and is expected to make a significant contribution to the pathological analysis of patient self-inflicted lung injury, including the pendelluft phenomenon.

Free Research Field

人工呼吸, 集中治療

Academic Significance and Societal Importance of the Research Achievements

今まで解剖学的な情報を把握しながら肺局所の換気動態を評価可能なイメージングモダリティが存在しなかった。しかし、本研究により4D-CTが人工呼吸中の肺換気動態を正確に評価できることが証明された。今まで解明されていなかった自発呼吸による肺傷害をさらに深く解析することが可能となったことから、4D-CTが個別化した安全な人工呼吸管理を行うためのイメージングモダリティとして重要な役割を果たすことが期待される。