2023 Fiscal Year Final Research Report
Analysis of the therapeutic effect of metabolites secreted from Lipogems-treated adipose tissue on knee osteoarthritis
| Project/Area Number |
21K16666
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 脂肪由来幹細胞 / メタボローム / トランスクリプトーム |
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| Outline of Final Research Achievements |
Fragmented adipose tissue prepared with kits such as Lipogems and adipose-derived stem cells have been used for the treatment of osteoarthritis of the knee. Recently, metabolites have been shown to have various physiological effects, but it was unclear whether the metabolites secreted by adipose-derived stem cells have therapeutic (anti-inflammatory) effects. Metabolomic analysis performed in this study revealed that human adipose-derived stem cells secreted a large amount of metabolite X. Exposure of macrophages to metabolite X suppressed the expression of genes involved in inflammatory responses, indicating that metabolites also contribute to the therapeutic effect of adipose-derived stem cells.
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| Free Research Field |
整形外科学
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化を背景に、変形性膝関節症患者は世界的に増加している。軽症患者にはヒアルロン酸やステロイド等が投与されているが、その効果には限界がある。近年、脂肪組織の破砕物や脂肪由来幹細胞による変形性膝関節症治療が広まりつつあり、一定の治療効果が認められている。これまで、脂肪由来幹細胞による治療効果はサイトカインやエクソソームによって担われていると考えられてきたが、本研究から、Xを含む代謝産物が「第3の治療因子」であることが示唆された。
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