2023 Fiscal Year Final Research Report
Evaluation of Autogenous Bone Grafting after Devitalization by High Hydrostatic Pressure
| Project/Area Number |
21K16704
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 高圧処理 / 骨移植 / 脊椎後側方固定 / 骨腫瘍 / 殺細胞処理 / 処理骨移植 / 腫瘍不活化 |
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| Outline of Final Research Achievements |
The results of this study show that high hydrostatic pressure (HHP) treated bone grafting is a useful treatment method that can achieve bone fusion. With regard to the time of bone healing, the early bone fusion rate was inferior in the HHP group compared to the fresh autogenous group, but the long-term bone healing rates were comparable. Although the HHP treatment could not be shown to be superior to liquid nitrogen treatment, the fact that it was comparable or superior to liquid nitrogen treatment, which is already in clinical use, suggests that it is clinically applicable. The results of degeneration of the treated bones by electroscope showed less degeneration with the HHP treatment than with liquid nitrogen, suggesting that the mechanical properties may be superior to those of liquid nitrogen.
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| Free Research Field |
整形外科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により骨腫瘍の殺細胞処理の一つとして高圧処理が有用である可能性が示された。さらなる安全性や有効性の検討・研究が必要ではあるが、本研究成果は高圧処理が臨床応用されるために必須となる重要な成果である。既存の処理方法は骨腫瘍のみを対象とするものであったが、高圧処理は皮膚腫瘍に対しても有効性が示されており、皮膚と骨の2つの臓器を扱う全く新しい処理方法である。さらなる検討を進め、骨腫瘍患者に対して有効な治療選択肢となるよう研究を進めていく予定である。
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