Low intensity shockwave and PDE5 inhibitor for underactive bladder

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16729
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Tohoku University
• Principal Investigator: Sato Takuma 東北大学, 大学病院, 助教 (80804856)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: underactive bladder / PDE5 inhibitor / shock wave

Outline of Final Research Achievements

Underactive bladder may be associated with severe voiding dysfunction. Decreased blood flow to the bladder can contribute to the pathology. In this study, attempts were made to develop an animal model of underactive bladder. In addition, the animals were treated with PDE5 inhibitor and low-intensity shock wave, which had been shown to improve in blood flow to the bladder. Herein, increase in blood flow to their bladder was observed when they were treated with PDE5 inhibitor alone, low-intensity shock wave exposure alone, and the combinations. However, improvement in underactive bladder was not demonstrated.

Free Research Field

泌尿器科

Academic Significance and Societal Importance of the Research Achievements

低活動膀胱は下部尿路症状を有する多くの症例の病態に関連しており、（高度な）排出障害の原因になっていることが推察される。現時点でこの病態を根本的に改善させる治療法は確立していない。今回は、血流障害に起因する低活動膀胱に対する新規治療法（PDE5阻害薬および低出力衝撃波照射）の開発を目指して研究を行った。その結果、上記治療による膀胱血流の改善は認められたが低活動膀胱自体の改善は明らかではなかった。今後は治療効果の安定的な評価が可能となる動物モデルの作製を含め、本病態を改善させる治療法の開発を引き続き行っていく予定である。