It could improve embryonic development and postnatal development by managing the lipid droplets in eggs.

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16809
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TATSUMI TAKAYUKI 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (30846035)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 受精卵 / 脂肪酸

Outline of Final Research Achievements

It has been reported that omega-3 fatty acid intake during the period from pregnancy to lactation may reduce the risk ratio of developing food allergies to chicken eggs and peanuts. We reported that by feeding mice with a high-fat diet for an extremely short period of time, fatty acids in the blood and follicular fluid increase the number of lipid droplets inside the egg through gap junctions. This means that the components are reflected in the eggs themselves more quickly and to a greater extent than previously thought. From the perspective of the environment surrounding eggs, taking into account the possibility that fatty acids in recent meals may affect the eggs themselves, consuming omega-3 fatty acids before pregnancy may also be effective.

Free Research Field

生殖医療

Academic Significance and Societal Importance of the Research Achievements

不妊治療において、妊孕性を少しでも改善させる方法が求められている。妊娠から授乳までの期間にオメガ3脂肪酸を摂取することで、鶏卵やピーナッツへの食物アレルギーの発症リスク比を低下させる可能性が報告されている。筆者らはマウスに超短期間の高脂肪食を負荷することで、血液・卵胞液中の脂肪酸がギャップ結合を通じて卵子内部の脂肪滴を増加させることを報告した。これらは直前の食事中の成分が今まで考えられていたよりもより早く、より大きく卵子そのものに反映されることを意味している。直近の食事に含まれる脂肪酸が卵そのものに影響を与える可能性を考慮し、妊娠前からのオメガ3脂肪酸の摂取も有効な可能性がある。