Transcription factor analysis involved in Napsin A expression in ovarian clear cell carcinoma

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16820
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Dokkyo Medical University
• Principal Investigator: Iwamoto Masami 獨協医科大学, 医学部, 協力研究員 (30826649)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 卵巣癌 / 明細胞癌 / Napsin A / 転写因子解析

Outline of Final Research Achievements

Napsin A is known as a marker for peripheral-type lung adenocarcinoma, but it is also frequently expressed in clear cell carcinoma of the ovary and endometrium. However, the mechanism of Napsin A expression in clear cell carcinoma remains unresolved. In this study, we analyzed transactivators that may be involved in NAPSA gene activation, focusing upon four kinds of transcription factors (A, B, C, and D). As a result, Napsin A expression tended to be increased by transcription factor D and by co-expression of two kinds of transcription factors C and D. This study could provide valuable insights in tumorigenesis of ovarian clear cell carcinoma.

Free Research Field

病理学、婦人科腫瘍、卵巣腫瘍

Academic Significance and Societal Importance of the Research Achievements

卵巣明細胞癌は本邦において多く見られ、化学療法に対する感受性が低いことから進行例は予後不良な腫瘍である。卵巣明細胞癌においてNapsin Aが高発現していることは広く知られるところとなったが、その発現機序はいまだ明らかにされておらず、本研究成果はその解明に一歩近づいたと言える。卵巣癌において明細胞癌に比較的特異的に発現するNapsin Aの発現機序の一端を明らかにした本研究成果は、腫瘍発生メカニズムの解明に繋がるものと思われる。