Elucidation of the inhibitory mechanism for periodontal disease pathological changes in diabetic patients and establishment of new treatment methods

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K16979
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: The Nippon Dental University
• Principal Investigator: Maruyama Kosuke 日本歯科大学, 新潟生命歯学部, 助教 (60756930)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 歯周病 / 糖尿病 / 血管内皮細胞 / Nd-YAGレーザー

Outline of Final Research Achievements

The purpose of this study is to elucidate the inhibitory mechanism of pathological changes in periodontal disease in diabetic patients using vascular endothelial cells derived from human periodontal tissue, and to elucidate the physiological activity of periodontal tissues by laser treatment. First, this study focused on vascular endothelial cells, which play an important role in the immune response in periodontal tissues, and examined the cellular changes that occur when patients are affected by diabetes. As a result, it was revealed that when patients are affected by diabetes, vascular endothelial cells show stagnant cell proliferation and secrete more proteins that promote inflammation compared to normal cases. It was also revealed that laser irradiation of vascular endothelial cells affected by diabetes may promote cell proliferation.

Free Research Field

歯周病

Academic Significance and Societal Importance of the Research Achievements

歯周病と糖尿病に罹患する人は、年々増加している中、糖尿病に罹患した際に歯周組織にどのような変化が起こっているかは未だ不明な点が多い。本研究は歯周組織の免疫応答で重要な役割を果たしている血管内皮細胞に注目している。研究成果から、糖尿病に罹患した場合、歯周組織の血管内皮細胞の活動性が低下することが明らかになった。一方、糖尿病に罹患した歯周組織に低出力のレーザーを照射することで、活動性が低下した血管内皮細胞の動きを回復させる可能性についても明らかとした。これは、糖尿病患者が歯周病に罹患した際の、新たな歯周治療法となると考える。