Development of a new bone regeneration method based on regulation of macrophage polarization by Titanium Surface Modification

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K17020
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Nagoya University
• Principal Investigator: Toyama Naoto 名古屋大学, 医学部附属病院, 客員研究者 (30877098)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 骨再生 / 骨区域欠損 / 血管新生 / マクロファージ / 間葉系幹細胞

Outline of Final Research Achievements

In this study, the effect of activation of macrophages adhering to surface-treated titanium on the construction of blood vessels was investigated.
Mechanical polishing and acid treatment, both of which can be easily performed as titanium surface treatments, were compared. Angiogenesis was significantly decreased in the acid-treated group as well as gene expression in the effect on tube formation of human umbilical vein endothelial cells. Further studies on the conditions of titanium treatment and analysis of the relationship with bone formation are needed.

Free Research Field

骨再生

Academic Significance and Societal Importance of the Research Achievements

顎口腔領域における骨再生法は確立されつつあるが大規模骨欠損の組織再生には課題が多く、効率的な組織再生には血流の確保が重要となる。生体材料は欠くことのできない要素であり、自己の再生力を最大限引き出すためには初期に応答するマクロファージの挙動をコントロールすることが有効であると考え、本研究では顎口腔領域の骨再生や再建で用いられる頻度の高いチタンの表面性状を改変しマクロファージの挙動の変化を観察し新たな視点を示した。